S&P Brain
| Pre-Clinical Studies & In Vivo Research Services
Your trusted partner for preclinical validation, from concept to confidence.
Who We Are ?
At SP Brain, we deliver end-to-end in vivo proof-of-concept research to support the critical transition from lab to clinic. We partner with pharmaceutical, biotechnology, and medical device companies to design, execute, and interpret preclinical studies with rigor and reliability.
MISSION
S&P BRAIN provides complete in vivo proof-of-concept research to meet the needs of pharmaceuticals, biotechnology and medical devices companies or research centers. Our aim is to offer high quality experimental studies leading to reliable results required for the preclinical phase. We have the experience and the expertise, to guide start up, research labs and companies to reach their goal.
-Overview-
S&P BRAIN is a CRO located in Orbassano, few kilometers away from Turin, in the heart of an excellent environment that hosts two universities of applied sciences, several research institutes and the Biotechnological park of Ivrea. S&P BRAIN’s headquarter and preclinical research unit are located in NICO, a new research center devoted to Neurosciences that gathers the complementary experiences of eight research groups sharing of knowledge, expertise, capabilities and facilities, thereby creating a very collaborative and highly stimulating scientific atmosphere. We offer preclinical studies in small animals spanning from a wide range of behavioral tests to models of neurological injuries to cardiovascular, endocrine and metabolic measures.
S&P BRAIN is a young company founded by a group of senior academic professors and researchers working in the neuroscientific and pharmacological field. The idea came from the necessity of private companies to outsource the execution of in vivo tests concerning the development of new compounds or the characterization of new mouse models.
Our company has an extensive knowledge in the neuroscience field, that is supported by the long term expertise of its staff active in an internationally recognized academic research. Team’s know-how covers a wide variety of multidisciplinary research activities applied to neurosciences, including neuroanatomy, neurophysiology, neuropharmacology, neuro-regenerative medicine, cellular and molecular biology. S&P BRAIN is led by a group of senior academic professors and researchers with decades of expertise in the neuroscience field, honed in prestigious international and Italian Universities and Research Centers.
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Environment effects
-Perinatal environment
-Enriched environment
-Constraint-induced movement therapy (CIMT)
Addiction
-Alcohol addiction
-Chocolate or palatable food addiction
-Compulsive eating
Brain tumor models
-In vivo models of glioblastoma (grafts of mouse or human glioblastoma cell lines)
-In vivo pharmacological treatments
-MRI-based longitudinal analyses
-Histological investigations
-End-point analyses
Cognitive tests
-Learning and memory
-Problem solving
Functional tests
-Locomotor activity
-Spontaneous locomotor activity
-Feeding behavior
-Sexual behavior
-Heart rate and blood pressure
-Oxygen saturation, breath rate, pulse and breath distention
Analysis of developmental milestones
-Body weight, pinnae detachment, eye opening, incisor eruption
-Righting reflex, visual placing
-Negative geotaxis, tactile startle
-Nest seeking response
-Auditory startle
-Bar holding and vertical screen.
-Clasping behavior
What We Do ?
Services & Expertise
- Efficacy & Pharmacology Studies
Test dr ug candidates in animal models to demonstrate biological activity, dose response, and target engagement.
- Toxicology & Safety Assessments
Evaluate safety margins, dose tolerability, organ-specific toxicity, and long-term effects.
- Disease Modeling
Leverage validated animal models of disease (neurology, oncology, metabolic, immunology) to predict human relevance.
- Biomarker & Endpoint Analysis
Measure molecular, cellular, and functional biomarkers to strengthen translational insights.
- Study Design & Consultation
Benefit from our scientific input on protocol design, statistical power, and regulatory alignment.
=> Each study is customized, with robust quality control, data transparency, and adherence to ethical and regulatory guidelines.
S&P BRAIN supplies a wide range of functional and psycho-emotional behavioral tests, neurological injury models, brain tumor models, surgical techniques with rodents as well as cardiovascular, endocrine and metabolic measures.
S&P BRAIN can provide several genetically engineered mouse models of pathologies of the nervous and endocrine systems. We also have the experience and knowledge needed to design new wild type or mutant mouse models for preclinical proof of concept studies that are requested by our clients.
S&P BRAIN can provide sophisticated morphological analyses (stereology and confocal, electron, two photon and light sheet microscopy) and biomolecular (mRNA and protein gene expression) analyses.
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